RNA G-quadruplex structure contributes to cold adaptation in plants

Yang, Xiaofei, Yu, Haopeng, Duncan, Susan, Zhang, Yueying, Cheema, Jitender, Liu, Haifeng, Miller, J. Benjamin ORCID: https://orcid.org/0000-0003-0882-033X, Zhang, Jie, Kwok, Chun Kit, Zhang, Huakun and Ding, Yiliang (2022) RNA G-quadruplex structure contributes to cold adaptation in plants. Nature Communications, 13. ISSN 2041-1723

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Abstract

Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown. Here, we systematically analyze the nucleotide composition of transcriptomes across 1000 plants (1KP) and their corresponding habitats. Intriguingly, we find that plants growing in cold climates have guanine (G)-enriched transcriptomes, which are prone to forming RNA G-quadruplex structures. Both immunofluorescence detection and in vivo structure profiling reveal that RNA G-quadruplex formation in plants is globally enhanced in response to cold. Cold-responsive RNA G-quadruplexes strongly enhanced mRNA stability, rather than affecting translation. Disruption of individual RNA G-quadruplex promotes mRNA decay in the cold, leading to impaired plant cold response. Therefore, we propose that plants adopted RNA G-quadruplex structure as a molecular signature to facilitate their adaptation to the cold during evolution.

Item Type:	Article
Additional Information:	Acknowledgements: The study is supported by the National Natural Science Foundation of China (32170229) (H.Z.), the National Key Research and Development Program of China (2021YFF1000900) (H.Z.), United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC: BBS/E/J/000PR9788, BB/L025000/1, and BB/N022572/1) (Y.D.), Norwich Research Park Science links seed fund (Y.D.), the European Research Council (ERC: 680324) (Y.D.), Human Frontier Science Program Fellowship (LT001077/2021-L) (H.Y.), Shenzhen Basic Research Project (JCYJ20180507181642811) (C.K.K.), Research Grants Council of the Hong Kong SAR, China Projects (CityU 11100421, CityU 11101519, CityU 11100218 and N_CityU110/17) (C.K.K.), Croucher Foundation Project (9509003)(C.K.K), State Key Laboratory of Marine Pollution Director Discretionary Fund (C.K.K.).
Uncontrolled Keywords:	chemistry(all),biochemistry, genetics and molecular biology(all),general,physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences Faculty of Science > Research Groups > Molecular Microbiology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	12 Oct 2022 14:33
Last Modified:	02 Nov 2022 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/89010
DOI:	10.1038/s41467-022-34040-y

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