Obsessive-compulsive disorder: Puzzles and prospects

Robbins, Trevor W., Vaghi, Matilde M. ORCID: https://orcid.org/0000-0002-0999-9055 and Banca, Paula (2019) Obsessive-compulsive disorder: Puzzles and prospects. Neuron, 102 (1). pp. 27-47. ISSN 0896-6273

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Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents several challenges for neuroscience. Recent advances in its genetic and developmental causation, as well as its neuropsychological basis, are reviewed. Hypotheses concerning an imbalance between goal-directed and habitual behavior together with neural correlates in cortico-striatal circuitry are evaluated and contrasted with metacognitive theories. Treatments for obsessive-compulsive disorder (OCD) tend to be of mixed efficacy but include psychological, pharmacological, and surgical approaches, the underlying mechanisms of which are still under debate. Overall, the prospects for new animal models and an integrated understanding of the pathophysiology of OCD are considered in the context of dimensional psychiatry.

Item Type: Article
Faculty \ School: Faculty of Social Sciences > School of Psychology
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 04 Oct 2022 16:30
Last Modified: 04 Mar 2024 18:13
URI: https://ueaeprints.uea.ac.uk/id/eprint/88838
DOI: 10.1016/j.neuron.2019.01.046


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