Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity

Vaghi, Matilde M. ORCID:, Moutoussis, Michael, Váša, František, Kievit, Rogier A., Hauser, Tobias U., Vértes, Petra E., Shahar, Nitzan, Romero-Garcia, Rafael, Kitzbichler, Manfred G., Bullmore, Edward T. and Dolan, Raymond J. and NSPN Consortium (2020) Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity. Proceedings of the National Academy of Sciences of the United States of America, 117 (41). pp. 25911-25922. ISSN 0027-8424

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A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been linked also to abnormal frontostriatal connectivity. However, the developmental trajectory of model-based control, including an interplay between its maturation and an emergence of compulsivity, has not been characterized. Availing of a large sample of healthy adolescents (n = 569) aged 14 to 24 y, we show behaviorally that over the course of adolescence there is a within-person increase in model-based control, and this is more pronounced in younger participants. Using a bivariate latent change score model, we provide evidence that the presence of higher compulsivity traits is associated with an atypical profile of this developmental maturation in model-based control. Resting-state fMRI data from a subset of the behaviorally assessed subjects (n = 230) revealed that compulsivity is associated with a less pronounced change of within-subject developmental remodeling of functional connectivity, specifically between the striatum and a frontoparietal network. Thus, in an otherwise clinically healthy population sample, in early development, individual differences in compulsivity are linked to the developmental trajectory of model-based control and a remodeling of frontostriatal connectivity.

Item Type: Article
Additional Information: Data Availability: Data have been deposited on Open Science Framework (
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 04 Oct 2022 13:01
Last Modified: 07 Mar 2024 02:39
DOI: 10.1073/pnas.1922273117


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