The early-life gut microbiome and vaccine efficacy

Jordan, Anne, Carding, Simon R and Hall, Lindsay J ORCID: (2022) The early-life gut microbiome and vaccine efficacy. The Lancet Microbe, 3 (10). E787-E794. ISSN 2666-5247

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Vaccines are one of the greatest successes of public health, preventing millions of cases of disease and death in children each year. However, the efficacy of many vaccines can vary greatly between infants from geographically and socioeconomically distinct locations. Differences in the composition of the intestinal microbiome have emerged as one of the main factors that can account for variations in immunisation outcomes. In this Review, we assess the influence of the gut microbiota upon early life immunity, focusing on two important members of the microbiota with health-promoting and immunomodulatory properties: Bifidobacterium and Bacteroides. Additionally, we discuss their immune stimulatory microbial properties, interactions with the host, and their effect on vaccine responses and efficacy in infants. We also provide an overview of current microbiota-based approaches to enhance vaccine outcomes, and describe novel microbe-derived components that could lead to safer, more effective vaccines and vaccine adjuvants.

Item Type: Article
Additional Information: Funding Information: LJH is supported by Wellcome Trust Investigator Awards (100974/C/13/Z and 220876/Z/20/Z). LJH and SRC are also supported by Biotechnology and Biological Sciences Research Council (BBSRC), Institute Strategic Programme Gut Microbes and Health (BB/R012490/1) and its constituent projects (BBS/E/F/000PR10353, BBS/E/F/000PR10355, and BBS/E/F/000PR10356), and a BBSRC Norwich Research Park Bioscience Doctoral Training grant (BB/M011216/1; supervisors LJH and SRC, student AJ).
Uncontrolled Keywords: microbiology (medical),infectious diseases,virology,microbiology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2726
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
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Depositing User: LivePure Connector
Date Deposited: 30 Sep 2022 12:31
Last Modified: 18 Apr 2023 15:30
DOI: 10.1016/s2666-5247(22)00185-9


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