Engineering Tobacco for Plant Natural Product Production

Stephenson, Michael ORCID:, Reed, James, Patron, Nicola J, Lomonossoff, George P and Osbourn, Anne (2020) Engineering Tobacco for Plant Natural Product Production. In: Comprehensive Natural Products III. Elsevier, pp. 244-262. ISBN 9780081026915

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Plants are a rich source of drugs and other useful molecules. However, the vast majority of plant natural products remain unexploited because of the challenges of accessing source species, purifying low abundance molecules from plant extracts, and intractability to chemical synthesis. The wealth of plant genome sequence data is greatly accelerating the discovery of candidate genes for plant specialized metabolism. The bottleneck now lies in translating predicted gene sequences into chemistry. Microorganisms are the traditional hosts of choice for development of commercial-scale metabolic engineering platforms by industry. However, plants, in particular relatives of tobacco, hold considerable potential as heterologous hosts for engineering production of high-value metabolites derived from other plant species and have a number of advantages over microbes. Here we review progress in this area and consider the application of heterologous plant expression for metabolic engineering of one of the largest classes of plant natural products, the terpenes.

Item Type: Book Section
Uncontrolled Keywords: heterologous production,metabolic engineering,natural products,nicotiana benthamiana,peaq vectors,plant production platforms,plant specialized metabolism,secondary metabolites,tobacco,transient plant expression,triterpene
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Life Processes
Depositing User: LivePure Connector
Date Deposited: 28 Sep 2022 09:30
Last Modified: 15 Dec 2022 01:02
DOI: 10.1016/B978-0-12-409547-2.14724-9

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