Genome-wide analysis of human long noncoding RNAs: A provocative review

Ponting, Chris P. and Haerty, Wilfried ORCID: (2022) Genome-wide analysis of human long noncoding RNAs: A provocative review. Annual Review of Genomics and Human Genetics, 23. pp. 153-172. ISSN 1545-293X

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Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To address how lncRNA loci and their transcripts, structures, interactions, and functions contribute to human traits and disease, we adopt a genome-wide perspective. We intend to provoke alternative interpretation of questionable evidence and thorough inquiry into unsubstantiated claims. We discuss pitfalls of lncRNA experimental and computational methods as well as opposing interpretations of their results. The majority of evidence, we argue, indicates that most lncRNA transcript models reflect transcriptional noise or provide minor regulatory roles, leaving relatively few human lncRNAs that contribute centrally to human development, physiology, or behavior. These important few tend to be spliced and better conserved but lack a simple syntax relating sequence to structure and mechanism, and so resist simple categorization. This genome-wide view should help investigators prioritize individual lncRNAs based on their likely contribution to human biology.

Item Type: Article
Uncontrolled Keywords: evolutionary constraint,knockout phenotype,molecular mechanism,rna structure,subcellular localization,transcriptional noise,molecular biology,genetics,genetics(clinical),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
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Depositing User: LivePure Connector
Date Deposited: 21 Sep 2022 17:30
Last Modified: 14 Jun 2023 14:10
DOI: 10.1146/annurev-genom-112921-123710


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