Sleep disturbances in Lewy body dementia: A systematic review

Elder, Greg J., Lazar, Alpar S., Alfonso-Miller, Pam and Taylor, John-Paul (2022) Sleep disturbances in Lewy body dementia: A systematic review. International Journal of Geriatric Psychiatry, 37 (10). pp. 1-22. ISSN 0885-6230

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Background: Lewy body dementia (LBD) refers to both dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). Sleep disturbances are common in LBD, and can include poor sleep quality, excessive daytime sleepiness (EDS), and rapid eye movement behaviour disorder (RBD). Despite the high clinical prevalence of sleep disturbances in LBD, they are under-studied relative to other dementias. The aim of the present systematic review was to examine the nature of sleep disturbances in LBD, summarise the effect of treatment studies upon sleep, and highlight specific and necessary directions for future research. Methods: Published studies in English were located by searching PubMED and PSYCArticles databases (until 10 June 2022). The search protocol was pre-registered in PROSPERO (CRD42021293490) and performed in accordance with PRISMA guidelines. Results: Following full-text review, a final total of 70 articles were included. These included 20 studies focussing on subjective sleep, 14 on RBD, 8 on EDS, 7 on objective sleep, and 1 on circadian rhythms. The majority of the 18 treatment studies used pharmacological interventions (n = 12), had an open-label design (n = 8), and were of low-to-moderate quality. Most studies (n = 55) included only patients with DLB. Due to the heterogeneity of the studies, we reported a narrative synthesis without meta-analysis. Conclusions: At least one form of sleep disturbance may be present in as many as 90% of people with LBD. Subjectively poor sleep quality, excessive daytime sleepiness, and RBD are more common and severe in LBD relative to other dementias.

Item Type: Article
Additional Information: Research Funding: National Institute for Health Research Newcastle Biomedical Research Unit; Alzheimer’s Research UK. Grant Number: ARUK-PPG2020A-028; British Sleep Society; Alzheimer's Research UK North Network Centre
Uncontrolled Keywords: lewy body dementia,parkinson’s disease dementia,dementia with lewy bodies,sleep,sleep disturbances,sleepiness,geriatrics and gerontology,psychiatry and mental health ,/dk/atira/pure/subjectarea/asjc/2700/2717
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: LivePure Connector
Date Deposited: 16 Sep 2022 13:36
Last Modified: 19 Oct 2023 03:25
DOI: 10.1002/gps.5814


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