Evolution of genes and genomes on the Drosophila phylogeny

Drosophila 12 Genomes Consortium (2007) Evolution of genes and genomes on the Drosophila phylogeny. Nature, 450 (7167). pp. 203-218. ISSN 0028-0836

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Abstract

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.

Item Type: Article
Additional Information: Acknowledgements Agencourt Bioscience Corporation, The Broad Institute of MIT and Harvard and the Washington University Genome Sequencing Center were supported by grants and contracts from the National Human Genome Research Insititute (NHGRI). T.C. Kaufman acknowledges support from the Indian Genomics Initiative.
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 15 Sep 2022 15:31
Last Modified: 22 Sep 2022 19:34
URI: https://ueaeprints.uea.ac.uk/id/eprint/88342
DOI: 10.1038/nature06341

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