No gene in the genome makes sense except in the light of evolution

Haerty, Wilfried ORCID: and Ponting, Chris P. (2014) No gene in the genome makes sense except in the light of evolution. Annual Review of Genomics and Human Genetics, 15. pp. 71-92. ISSN 1527-8204

Full text not available from this repository. (Request a copy)


Evolutionary conservation has been an accurate predictor of functional elements across the first decade of metazoan genomics. More recently, there has been a move to define functional elements instead from biochemical annotations. Evolutionary methods are, however, more comprehensive than biochemical approaches can be and can assess quantitatively, especially for subtle effects, how biologically important-how injurious after mutation-different types of elements are. Evolutionary methods are thus critical for understanding the large fraction (up to 10%) of the human genome that does not encode proteins and yet might convey function. These methods can also capture the ephemeral nature of much noncoding functional sequence, with large numbers of functional elements having been gained and lost rapidly along each mammalian lineage. Here, we review how different strengths of purifying selection have impacted on protein-coding and non-protein-coding loci and on transcription factor binding sites in mammalian and fruit fly genomes.

Item Type: Article
Uncontrolled Keywords: molecular function,neutral evolution,noncoding,regulatory element,selection,molecular biology,genetics,genetics(clinical) ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 15 Sep 2022 14:30
Last Modified: 19 Apr 2023 01:13
DOI: 10.1146/annurev-genom-090413-025621

Actions (login required)

View Item View Item