Antimicrobial resistance and co-selection phenomenon in Listeria spp. recovered from food and food production environments

Kovacevic, Jovana, Sagert, Jason, Wozniak, Anna, Gilmour, Matthew W. and Allen, Kevin J. (2013) Antimicrobial resistance and co-selection phenomenon in Listeria spp. recovered from food and food production environments. Food Microbiology, 34 (2). pp. 319-327. ISSN 0740-0020

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Abstract

Antimicrobial resistance (AMR), co-selection phenomenon, and the relationship between reduced susceptibility (RSC) to ciprofloxacin (CIP) and resistance to other antimicrobials in Listeria spp. (n = 103) recovered from food processing environments (FPE) and food were investigated. Resistance of Listeria monocytogenes and other listeriae, respectively, to cefoxitin (FOX; 98% vs. 88%), CIP (7% vs. 4%), clindamycin (CLI; 33% vs. 59%) and tetracycline (6% vs. 8%) was observed, as was RSC to CIP (67% vs. 57%) and CLI (65% vs. 41%). L. monocytogenes also possessed RSC to linezolid (LZD; 6%), rifampicin (2%) and streptomycin (6%), with other listeriae displaying RSC to chloramphenicol (4%). L. monocytogenes serotype 1/2a (90%) isolates were more frequently resistant or possessed RSC to CIP compared to serotype 4b (55%) (p = 0.015). When eight strains were experimentally adapted to high concentrations of CIP, co-selection occurred as MICs to benzalkonium chloride (BAC) increased (n = 5), gentamicin MICs remained the same (n = 6) or increased 2-fold (n = 2), and led to RSC to LZD (n = 1) and resistance to CLI (n = 8). Overall, levels of resistance/RSC to CIP in food chain isolates, particularly 1/2a, are concerning. Further, reduced sensitivity to disparate antimicrobials following CIP exposure highlights the need for increased knowledge of co-selection phenomenon linked with antimicrobial agents.

Item Type: Article
Additional Information: Funding Information: This work was supported by the National Sciences and Engineering Research Council of Canada . We would like to acknowledge British Columbia Centre for Disease Control for donating bacterial isolates, and the Canadian National Microbiology Laboratory for performing serotyping. We also extend our thanks to Dr. Lili Mesak and Wenqian Yuan for their technical assistance.
Uncontrolled Keywords: antimicrobial resistance,co-selection,cross-resistance,efflux pump,listeria monocytogenes,listeria spp.,food science,microbiology,sdg 2 - zero hunger ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 14 Sep 2022 09:30
Last Modified: 22 Sep 2022 19:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/88235
DOI: 10.1016/j.fm.2013.01.002

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