A novel Artificial Intelligence-based tool to assess anticholinergic burden: a survey

Secchi, Agostina, Mamayusupova, Hulkar, Sami, Saber, Maidment, Ian, Coulton, Simon, Myint, Phyo Kyaw and Fox, Chris ORCID: https://orcid.org/0000-0001-9480-5704 (2022) A novel Artificial Intelligence-based tool to assess anticholinergic burden: a survey. Age and Ageing, 51 (8). ISSN 0002-0729

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BACKGROUND: many medications possess anticholinergic activity. Their use is associated with a number of serious adverse effects including cognitive effects. The cumulative anticholinergic effect of medications as assessed by tools such as the anticholinergic burden scale (AchB) can identify people particularly at risk of anticholinergic side-effects. Currently, >20 tools are available for clinicians to use, but there is no consensus on the most appropriate tool. METHODS: a newly created online tool-International Anticholinergic Cognitive Burden Tool (IACT)-based on natural language processing and chemical structure analysis, was developed and made available for clinicians to test its functions. We carried out a survey (between 8th of February and 31st of March 2021) to assess the overall need for an assessment tool as well as the usability of the IACT. RESULTS: a total of 110 responses were received from different countries and practitioners' groups. The majority of the participants (86.11%) stated they would use a tool for AchB assessment if available and when they were asked to rate the IACT against other tools, amongst 34 responders, 20.59% rated it better and 8.82% rated it significantly better, 44.12% rated it neither better, nor worse, 14.71% rated it worse and 11.76% somewhat worse. CONCLUSION: there is a need for an anticholinergic burden calculator to assess the anticholinergicity of medications. Tools such as the IACT potentially could meet this demand due to its ability to assign scores to current and new medications appearing on the market based both on their chemical structure and reported adverse pharmacological effects.

Item Type: Article
Additional Information: Declaration of Sources of Funding: This work was funded by EIRA (Enabling Innovation: Research to Application) at UEA and Research England and Eastern AHSN.
Uncontrolled Keywords: adverse events,anticholinergic,older people,polypharmacy,ageing,geriatrics and gerontology ,/dk/atira/pure/subjectarea/asjc/1300/1302
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 13 Sep 2022 12:30
Last Modified: 21 Oct 2022 01:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/88215
DOI: 10.1093/ageing/afac196

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