A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Jing, Maofeng, Guo, Baodian, Li, Haiyang, Yang, Bo, Wang, Haonan, Kong, Guanghui, Zhao, Yao, Xu, Huawei, Wang, Yan, Ye, Wenwu, Dong, Suomeng, Qiao, Yongli, Tyler, Brett M., Ma, Wenbo and Wang, Yuanchao (2016) A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins. Nature Communications, 7. ISSN 2041-1723

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Abstract

Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

Item Type: Article
Uncontrolled Keywords: chemistry(all),biochemistry, genetics and molecular biology(all),physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/1600
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Depositing User: LivePure Connector
Date Deposited: 12 Sep 2022 12:30
Last Modified: 30 Sep 2022 02:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/88155
DOI: 10.1038/ncomms11685

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