Natural host-induced gene silencing offers new opportunities to engineer disease resistance

Hou, Yingnan and Ma, Wenbo (2020) Natural host-induced gene silencing offers new opportunities to engineer disease resistance. Trends in Microbiology, 28 (2). pp. 109-117. ISSN 0966-842X

Full text not available from this repository. (Request a copy)

Abstract

RNA silencing is an essential gene-regulation mechanism in eukaryotic organisms. Guided by small RNAs (sRNAs) of 20–25 nt in length, RNA silencing broadly governs a wide range of biological processes. In addition to regulating endogenous gene expression and inhibiting viral infection, accumulating evidence suggests that sRNAs can also function as antimicrobial agents against nonviral pathogens and directly silence gene targets in invading pathogen cells. Here, we summarize current understanding of this host-induced gene silencing (HIGS) process as a defense mechanism during natural infection. Specific focuses will be on recent advancement in the sRNA executors of HIGS and their potential delivery mechanisms from the plant host to filamentous eukaryotic pathogens, including fungi and Phytophthora species. Implications of these new findings in the applications of HIGS as a tool for engineering disease resistance is discussed.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2019 Elsevier Ltd
Uncontrolled Keywords:	extracellular vesicles,host-induced gene silencing,secondary sirna,trans-species rnai,microbiology,microbiology (medical),virology,infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2400/2404
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	12 Sep 2022 12:30
Last Modified:	20 Oct 2022 19:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/88144
DOI:	10.1016/j.tim.2019.08.009

Actions (login required)

View Item