Anvi'o:An advanced analysis and visualization platformfor 'omics data

Eren, A. Murat, Esen, Ozcan C., Quince, Christopher, Vineis, Joseph H., Morrison, Hilary G., Sogin, Mitchell L. and Delmont, Tom O. (2015) Anvi'o:An advanced analysis and visualization platformfor 'omics data. PeerJ, 2015 (10). ISSN 2167-8359

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Abstract

Advances in high-throughput sequencing and 'omics technologies are revolutionizing studies of naturally occurring microbial communities. Comprehensive investigations of microbial lifestyles require the ability to interactively organize and visualize genetic information and to incorporate subtle differences that enable greater resolution of complex data. Here we introduce anvi'o, an advanced analysis and visualization platform that offers automated and human-guided characterization of microbial genomes in metagenomic assemblies, with interactive interfaces that can link 'omics data from multiple sources into a single, intuitive display. Its extensible visualization approach distills multiple dimensions of information about each contig, offering a dynamic and unified work environment for data exploration, manipulation, and reporting. Using anvi'o, we re-analyzed publicly available datasets and explored temporal genomic changes within naturally occurring microbial populations through de novo characterization of single nucleotide variations, and linked cultivar and single-cell genomes with metagenomic and metatranscriptomic data. Anvi'o is an open-source platform that empowers researchers without extensive bioinformatics skills to performand communicate in-depth analyses on large 'omics datasets.

Item Type: Article
Additional Information: Publisher Copyright: © 2015 Eren et al.
Uncontrolled Keywords: assembly,genome binning,metagenomics,metatranscriptomics,snp profiling,visualization,neuroscience(all),biochemistry, genetics and molecular biology(all),agricultural and biological sciences(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 09 Sep 2022 09:31
Last Modified: 22 Sep 2022 19:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/88021
DOI: 10.7717/peerj.1319

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