Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice

van der Meer, Tiffany, Chan, W. Y.Iris, Palazon, Luis S., Nieduszynski, Conrad ORCID: https://orcid.org/0000-0003-2001-076X, Murphy, Martin, Sobczak-Thépot, Joëlle, Carrington, Mark and Colledge, William H. (2004) Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction, 127 (4). pp. 503-511. ISSN 1470-1626

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Abstract

In higher eukaryotes, the cyclins constitute a family of proteins involved in progression through the cell cycle. The cyclin A1 gene (Ccna1) is expressed during meiosis and is required for spermatogenesis. Targeted disruption of the Ccna1 gene with a LacZ reporter gene has allowed us to study the expression pattern of this gene in more detail. We have confirmed expression in mouse pre-meiotic spermatocytes and also detected expression in the accessory olfactory bulb, hippocampus and amygdala of the adult brain. We have also found that the amount of cyclin A1 protein influences the fertility of male mice and its action is modulated by genetic background. On an outbred genetic background (129S6/SvEv × MF1), Ccna1tm1Col -/- animals are sterile due to spermatogenic arrest prior to the first meiotic division while Ccna1tm1Col +/- mice show reduced sperm production and fertility. This is even more pronounced on an inbred genetic background (129S6/SvEv) where Ccna1tm1Col +/- male mice are sterile due to a severe reduction in the total number of sperm.

Item Type: Article
Uncontrolled Keywords: embryology,reproductive medicine,endocrinology,obstetrics and gynaecology,cell biology ,/dk/atira/pure/subjectarea/asjc/2700/2710
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 08 Sep 2022 08:31
Last Modified: 23 Sep 2022 02:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/87898
DOI: 10.1530/rep.1.00131

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