Dynamics of DNA replication in yeast

Retkute, Renata, Nieduszynski, Conrad A. ORCID: https://orcid.org/0000-0003-2001-076X and De Moura, Alessandro (2011) Dynamics of DNA replication in yeast. Physical Review Letters, 107 (6). ISSN 0031-9007

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Abstract

We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, that mean replication time curves cannot be used to directly determine origin parameters. We demonstrate that the stochastic nature of replication dynamics leaves a clear signature in experimentally measured population average data, and we show that the width of the activation time probability distribution can be inferred from this data. Our results compare favorably with experimental measurements in Saccharomyces cerevisae.

Item Type: Article
Uncontrolled Keywords: physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/3100
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 08 Sep 2022 08:30
Last Modified: 23 Sep 2022 02:47
URI: https://ueaeprints.uea.ac.uk/id/eprint/87888
DOI: 10.1103/PhysRevLett.107.068103

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