Cardiac magnetic resonance identifies raised left ventricular filling pressure: Prognostic implications

Garg, Pankaj ORCID:, Gosling, Rebecca, Swoboda, Peter, Jones, Rachel, Rothman, Alexander, Wild, Jim M., Kiely, David G., Condliffe, Robin, Alabed, Samer and Swift, Andrew J. (2022) Cardiac magnetic resonance identifies raised left ventricular filling pressure: Prognostic implications. European Heart Journal, 43 (26). pp. 2511-2522. ISSN 0195-668X

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Aims: Non-invasive imaging is routinely used to estimate left ventricular (LV) filling pressure (LVFP) in heart failure (HF). Cardiovascular magnetic resonance (CMR) is emerging as an important imaging tool for sub-phenotyping HF. However, currently, LVFP cannot be estimated from CMR. This study sought to investigate (i) if CMR can estimate LVFP in patients with suspected HF and (ii) if CMR-modelled LVFP has prognostic power. Methods and results: Suspected HF patients underwent right heart catheterization (RHC), CMR and transthoracic echocardiography (TTE) (validation cohort only) within 24 h of each other. Right heart catheterization measured pulmonary capillary wedge pressure (PCWP) was used as a reference for LVFP. At follow-up, death was considered as the primary endpoint. We enrolled 835 patients (mean age: 65 ± 13 years, 40% male). In the derivation cohort (n = 708, 85%), two CMR metrics were associated with RHC PCWP:LV mass and left atrial volume. When applied to the validation cohort (n = 127, 15%), the correlation coefficient between RHC PCWP and CMR-modelled PCWP was 0.55 (95% confidence interval: 0.41-0.66, P < 0.0001). Cardiovascular magnetic resonance-modelled PCWP was superior to TTE in classifying patients as normal or raised filling pressures (76 vs. 25%). Cardiovascular magnetic resonance-modelled PCWP was associated with an increased risk of death (hazard ratio: 1.77, P < 0.001). At Kaplan-Meier analysis, CMR-modelled PCWP was comparable to RHC PCWP (≥15 mmHg) to predict survival at 7-year follow-up (35 vs. 37%, χ2 = 0.41, P = 0.52). Conclusion: A physiological CMR model can estimate LVFP in patients with suspected HF. In addition, CMR-modelled LVFP has a prognostic role.

Item Type: Article
Additional Information: Funding: This work was supported by the National Institute for Health Research (NIHR-RP-R3-12-027) and The Wellcome Trust, (220703/Z/20/Z [] and 215799/Z/19/Z).
Uncontrolled Keywords: cardiovascular magnetic resonance,left ventricular filling pressure,right heart catheterization,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2705
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 14:30
Last Modified: 20 Oct 2022 18:30
DOI: 10.1093/eurheartj/ehac207

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