A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations

Brooks, Jonathan C.W. ORCID: https://orcid.org/0000-0003-3335-6209, Roberts, Neil, Kemp, Graham J., Gosney, Margot A., Lye, Michael and Whitehouse, Graham H. (2001) A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cerebral Cortex, 11 (7). pp. 598-605. ISSN 1047-3211

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Abstract

Ageing is associated with reduction of grey matter volume and it is reported that the frontal lobes are preferentially affected. We have applied quantitative magnetic resonance spectroscopy (MRS), incorporating measurement of brain tissue water content and metabolite T2 relaxation times, to determine absolute concentrations of the putative neuronal marker N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) compounds in the frontal lobe of 50 male subjects aged between 20 and 70 years (10 per decade). The fractional brain water content (βMR) did not change significantly as a function of age (r = 0.07, P = 0.65) and had a mean value of 81% (CV = 2%). The concentration (in millimoles per litre brain tissue) of NAA decreased significantly with age (r = -0.42, P = 0.003), with an overall decrease of 12% between the third and seventh decades. The concentrations of Cr and Cho did not change significantly with age. The interpretation of the age-dependent decrease in NAA concentration as reflecting either a reduction in neuronal volume, number or function is discussed.

Item Type: Article
Uncontrolled Keywords: cognitive neuroscience,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2805
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 12:31
Last Modified: 23 Sep 2022 02:45
URI: https://ueaeprints.uea.ac.uk/id/eprint/87824
DOI: 10.1093/cercor/11.7.598

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