Stimulus site and modality dependence of functional activity within the human spinal cord

Brooks, Jonathan C.W. ORCID: https://orcid.org/0000-0003-3335-6209, Kong, Yazhuo, Lee, Michael C., Warnaby, Catherine E., Wanigasekera, Vishvarani, Jenkinson, Mark and Tracey, Irene (2012) Stimulus site and modality dependence of functional activity within the human spinal cord. Journal of Neuroscience, 32 (18). pp. 6231-6239. ISSN 0270-6474

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Abstract

Chronic pain is thought to arise because of maladaptive changes occurring within the peripheral nervous system and CNS. The transition from acute to chronic pain is known to involve the spinal cord (Woolf and Salter, 2000). Therefore, to investigate altered human spinal cord function and translate results obtained from other species, anoninvasive neuro imaging techniqueis desirable. We have investigated the functional response in the cervical spinal cord of 18 healthy human subjects (aged 22-40years) to noxious thermal and non-noxious tactile stimulation of the left and right forearms. Physiological noise, which is a significant source of signal variability in the spinal cord, was accounted for in the general linear model. Group analysis, performed using a mixed-effects model, revealed distinct regions of activity that were dependent on both the side and the type of stimulation. In particular, thermal stimulation on the medial aspect of the wrist produced activity within the C6/C5 segment ipsilateral to the side of stimulation. Similar to data recorded in animals (Fitzgerald, 1982), painful thermal stimuli produced increased ipsilateral and decreased contralateral blood flow, which may reflect, respectively, excitatory and inhibitory processes. Non painful punctate stimulation of the thenar eminence provoked more diffuse activity but was still ipsilateral to the side of stimulation. These results present the first noninvasive evidence for a lateralized response to noxious and non-noxious stimuli in the human spinal cord. The development of these techniques opens the path to understanding, at a subject-specific level, central sensitization processes that contribute to chronic pain states.

Item Type: Article
Additional Information: Funding Information: This paper reports on part of the activities of the Grupo de Radiacidn Solar de Valencia and project CTIDIB/2002/113 funded by the regional government, the Generalitat Valenciana. We would like to thank the R+D+i Linguistic Assistance Office at the Universidad Politecnica of Valencia for their help in revising this paper.
Uncontrolled Keywords: neuroscience(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 11:31
Last Modified: 23 Sep 2022 02:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/87799
DOI: 10.1523/JNEUROSCI.2543-11.2012

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