Intrinsically organized resting state networks in the human spinal cord

Kong, Yazhuo, Eippert, Falk, Beckmann, Christian F., Andersson, Jesper, Finsterbusch, Jürgen, Büchel, Christian, Tracey, Irene and Brooks, Jonathan C.W. ORCID: https://orcid.org/0000-0003-3335-6209 (2014) Intrinsically organized resting state networks in the human spinal cord. Proceedings of the National Academy of Sciences of the United States of America, 111 (50). pp. 18067-18072. ISSN 0027-8424

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Abstract

Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain's principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord's functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system.

Item Type: Article
Uncontrolled Keywords: connectivity,fmri,networks,resting state,spinal cord,general,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1000
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 11:31
Last Modified: 23 Sep 2022 02:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/87792
DOI: 10.1073/pnas.1414293111

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