Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study

Demnitz, Naiara, Stathi, Afroditi, Withall, Janet, Stainer, Candida, Seager, Poppy, De Koning, Jolanthe, Esser, Patrick, Wassenaar, Thomas, Dawes, Helen, Brooks, Jonathan ORCID: https://orcid.org/0000-0003-3335-6209, Ebmeier, Klaus P., Johansen-Berg, Heidi and Sexton, Claire E. (2022) Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study. NeuroImage: Clinical, 35. ISSN 2213-1582

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Abstract

Background: Physical activity interventions have had varying results on modifying hippocampal volume.  Methods: The Retirement in Action (REACT) study conducted a randomised-controlled trial of a 12-month physical activity and behaviour maintenance intervention in older adults at risk of mobility impairments. The physical activity sessions were delivered twice weekly for the first twelve weeks, and then reduced to once weekly, to groups of 15 participants. Activities included cardiovascular, strength, balance and flexibility exercises. A sub-sample of participants in the physical activity (N = 54) and control arms (N = 48) underwent a 3 T MRI brain scan and cognitive assessments at baseline, 6- and 12-months (mean age = 76.6 years, 6.8 SD). It was hypothesised that the intervention would lead to a reduced rate of decline in hippocampal volume. Group differences in changes in cognition were also examined.  Results: As hypothesised, we found a maintenance in left hippocampal volume in the intervention arm, in comparison with the control arm after 12 months (p = 0.027). In a secondary analysis, this effect was attenuated after including age, sex and education level as covariates (p = 0.057). There was no significant between-group difference in the right hippocampus (p = 0.405). Contrary to our hypothesis, we did not find a beneficial effect of the intervention on cognitive outcomes.  Conclusions: Our findings suggest that a community-based physical activity intervention can significantly ward-off hippocampal atrophy in older adults. While the lack of effects on cognition may limit the interpretability of our results, our findings of hippocampal maintenance are promising given the potential clinical relevance of protecting the hippocampus from age-related decline.

Item Type: Article
Additional Information: Funding Information: This work was supported by the NIHR Public Health Research programme (13/164/ 51), NIHR Oxford Health Biomedical Research Centre (BRC) and the NIHR Oxford BRC based at Oxford University Hospitals NHS Trust and University of Oxford. HJB is supported by the Wellcome Trust (110027/Z/15/Z). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z).
Uncontrolled Keywords: ageing,exercise,hippocampus,mobility,rct,radiology nuclear medicine and imaging,neurology,clinical neurology,cognitive neuroscience ,/dk/atira/pure/subjectarea/asjc/2700/2741
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 11:30
Last Modified: 27 Sep 2022 08:26
URI: https://ueaeprints.uea.ac.uk/id/eprint/87780
DOI: 10.1016/j.nicl.2021.102762

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