Brain volumes and functional outcomes in children without cerebral palsy after therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy

Spencer, Arthur P. C., Lee-Kelland, Richard, Brooks, Jonathan C. W. ORCID: https://orcid.org/0000-0003-3335-6209, Jary, Sally, Tonks, James, Cowan, Frances M., Thoresen, Marianne and Chakkarapani, Ela (2022) Brain volumes and functional outcomes in children without cerebral palsy after therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy. Developmental Medicine and Child Neurology. ISSN 0012-1622

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Abstract

Aim: To investigate whether brain volumes were reduced in children aged 6 to 8 years without cerebral palsy, who underwent therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy (patients), and matched controls, and to examine the relation between subcortical volumes and functional outcome.   Method: We measured regional brain volumes in 31 patients and 32 controls (median age 7 years and 7 years 2 months respectively) from T1-weighted magnetic resonance imaging (MRI). We assessed cognition using the Wechsler Intelligence Scales for Children, Fourth Edition and motor ability using the Movement Assessment Battery for Children, Second Edition (MABC-2).  Results: Patients had lower volume of whole-brain grey matter, white matter, pallidi, hippocampi, and thalami than controls (false discovery rate-corrected p < 0.05). Differences in subcortical grey-matter volumes were not independent of total brain volume (TBV). In patients, hippocampal and thalamic volumes correlated with full-scale IQ (hippocampi, r = 0.477, p = 0.010; thalami, r = 0.452, p = 0.016) and MABC-2 total score (hippocampi, r = 0.526, p = 0.004; thalami, r = 0.505, p = 0.006) independent of age, sex, and TBV. No significant correlations were found in controls. In patients, cortical injury on neonatal MRI was associated with reduced volumes of hippocampi (p = 0.001), thalami (p = 0.002), grey matter (p = 0.015), and white matter (p = 0.013).  Interpretation: Children who underwent therapeutic hypothermia have reduced whole-brain grey and white-matter volumes, with associations between hippocampal and thalamic volumes and functional outcomes.

Item Type: Article
Additional Information: Funding Information: The Baily Thomas Charitable Fund (TRUST/VC/AC/SG4681‐7596), David Telling Charitable Trust, Sparks (05/BTL/01 and 14/BTL/01), and Moulton Foundation. A.P.C.S. is supported by the Wellcome Trust (WT220070/Z/20/Z). J.C.W.B. is supported by the UK Medical Research Council (MR/N026969/1).
Uncontrolled Keywords: pediatrics, perinatology, and child health,developmental neuroscience,clinical neurology ,/dk/atira/pure/subjectarea/asjc/2700/2735
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 11:30
Last Modified: 20 Oct 2022 18:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/87779
DOI: 10.1111/dmcn.15369

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