[18F]Sodium fluoride PET-MRI detects increased metabolic bone response to whole-joint loading stress in osteoarthritic knees

Watkins, Lauren E., Haddock, Bryan, Mackay, James W. ORCID: https://orcid.org/0000-0001-7558-3800, Baker, Janelle, Uhlrich, Scott D., Mazzoli, Valentina, Gold, Garry E. and Kogan, Feliks (2022) [18F]Sodium fluoride PET-MRI detects increased metabolic bone response to whole-joint loading stress in osteoarthritic knees. Osteoarthritis and Cartilage, 30 (11). pp. 1515-1525. ISSN 1063-4584

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Objective: Altered joint function is a hallmark of osteoarthritis (OA). Imaging techniques for joint function are limited, but [18F]sodium fluoride (NaF) PET-MRI may assess the acute joint response to loading stresses. [18F]NaF PET-MRI was used to study the acute joint response to exercise in OA knees, and compare relationships between regions of increased uptake after loading and structural OA progression two years later. Methods: In this prospective study, 10 participants with knee OA (59 ± 8 years; 8 female) were scanned twice consecutively using a PET-MR system and performed a one-legged squat exercise between scans. Changes in tracer uptake measures in 9 bone regions were compared between knees that did and did not exercise with a mixed-effects model. Areas of focally large changes in uptake between scans (ROIfocal, SUVmax > 3) were identified and the presence of structural MRI features was noted. Five participants returned two years later to assess structural change on MRI. Results: There was a significant increase in [18F]NaF uptake in OA exercised knees (SUV p < 0.001, Ki p = 0.002, K1 p < 0.001) that differed by bone region. Conclusion: There were regional differences in the acute bone metabolic response to exercise and areas of focally large changes in the metabolic bone response that might be representative of whole-joint dysfunction.

Item Type: Article
Additional Information: Funding Information: This work was funded by GE Healthcare, and the National Institutes of Health (NIH) grants R00EB022634, R01AR074492, R01AR077604, and R21EB030180.
Uncontrolled Keywords: osteoarthritis,knee,loading,pet,mri,imaging,knee,loading,imaging,osteoarthritis,biomedical engineering,rheumatology,orthopedics and sports medicine ,/dk/atira/pure/subjectarea/asjc/2200/2204
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 31 Aug 2022 14:08
Last Modified: 24 Oct 2022 06:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/87642
DOI: 10.1016/j.joca.2022.08.004

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