Micafungin for the treatment of invasive aspergillosis

Enoch, D. A., Idris, S. F., Aliyu, S. H., Micallef, C. ORCID: https://orcid.org/0000-0002-4513-8199, Sule, O. and Karas, J. A. (2014) Micafungin for the treatment of invasive aspergillosis. Journal of Infection, 68 (6). pp. 507-526. ISSN 0163-4453

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Abstract

Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients, particularly those with neutropenia and those undergoing bone marrow or stem cell transplants. Micafungin is an echinocandin antifungal drug with activity against all major Candida spp. Currently, micafungin is indicated for treatment of invasive candidiasis, oesophageal candidiasis and prophylaxis of Candida infection in patients undergoing allogeneic haematopoietic stem cell transplantation or patients who are expected to have neutropenia. Micafungin demonstrates invitro and invivo activity against Aspergillus spp. It is currently not licensed to treat Aspergillus infections in the UK or USA. This review summarises the current evidence base surrounding the clinical use of micafungin in the treatment of invasive aspergillosis to consider the potential role of micafungin in these patients. There are currently no randomised studies comparing micafungin with standard antifungal therapy. Prospective non-randomised clinical studies, predominantly performed in Japan, involving 492 patients with aspergillosis and 455 febrile patients with chemotherapy-induced neutropenia suggest that micafungin may be as effective as comparator antifungal agents. Other clinical evidence is limited to case reports. Further experience in the form of randomised controlled trials is required to establish the exact role of micafungin in the context of currently available broad-spectrum antifungal agents.

Item Type: Article
Uncontrolled Keywords: antifungal agents,aspergillus spp.,invasive aspergillosis,micafungin,microbiology (medical),infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2726
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 18 Aug 2022 08:31
Last Modified: 24 Sep 2022 07:05
URI: https://ueaeprints.uea.ac.uk/id/eprint/87416
DOI: 10.1016/j.jinf.2014.01.007

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