A whole-health–economy approach to antimicrobial stewardship: Analysis of current models and future direction

McLeod, Monsey, Ahmad, Raheelah, Shebl, Nada Atef, Micallef, Christianne ORCID: https://orcid.org/0000-0002-4513-8199, Sim, Fiona and Holmes, Alison (2019) A whole-health–economy approach to antimicrobial stewardship: Analysis of current models and future direction. PLoS Medicine, 16 (3). ISSN 1549-1277

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Abstract

- Antimicrobial stewardship (AMS) strategies are widely implemented in single healthcare sectors and organisations; however, the extent and impact of integrated AMS initiatives across the whole health economy are unknown. - Assessing degree of integration of AMS across the whole health economy and its impact is essential if we are to achieve a ‘One Health’ approach to addressing antimicrobial resistance (AMR), and therefore we searched systematically for and analysed published examples of integrated AMS initiatives to address this gap. - Application of a system-level framework to analyse integration of AMS initiatives across and within healthcare sectors shows that integration is emerging but needs strengthening. - Findings from a small number of evaluations in high-income countries suggest that antimicrobial prescribing and healthcare-associated infections can be reduced using a multisectoral integrated AMS approach. - More robust research designs to evaluate and understand the impact of multisectoral integrated AMS are needed, particularly with respect to differing health systems in different countries and local organisational contexts. - Our analysis highlights a number of challenges and ways forward for enhancing the delivery of AMS through an integrated approach.

Item Type: Article
Uncontrolled Keywords: medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 18 Aug 2022 08:30
Last Modified: 01 Oct 2022 07:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/87403
DOI: 10.1371/journal.pmed.1002774

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