A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector

Lin, Xiao, Olave-Achury, Andrea, Heal, Robert, Pais, Marina, Witek, Kamil, Ahn, Hee-Kyung ORCID: https://orcid.org/0000-0002-8884-0156, Zhao, He, Bhanvadia, Shivani, Karki, Hari S., Song, Tianqiao, Wu, Chih-Hang, Adachi, Hiroaki, Kamoun, Sophien ORCID: https://orcid.org/0000-0002-0290-0315, Vleeshouwers, Vivianne G. A. A. and Jones, Jonathan D. G. (2022) A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector. Molecular Plant, 15 (9). pp. 1457-1469. ISSN 1752-9867

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Species of the genus Phytophthora, the plant killer, cause disease and reduce yields in many crop plants. Although many Resistance to Phytophthora infestans (Rpi) genes effective against potato late blight have been cloned, few have been cloned against other Phytophthora species. Most Rpi genes encode nucleotide-binding domain, leucine-rich repeat-containing (NLR) immune receptor proteins that recognize RXLR (Arg-X-Leu-Arg) effectors. However, whether NLR proteins can recognize RXLR effectors from multiple Phytophthora species has rarely been investigated. Here, we identified a new RXLR-WY effector AVRamr3 from P. infestans that is recognized by Rpi-amr3 from a wild Solanaceae species Solanum americanum. Rpi-amr3 associates with AVRamr3 in planta. AVRamr3 is broadly conserved in many different Phytophthora species, and the recognition of AVRamr3 homologs by Rpi-amr3 activates resistance against multiple Phytophthora pathogens, including the tobacco black shank disease and cacao black pod disease pathogens P. parasitica and P. palmivora. Rpi-amr3 is thus the first characterized resistance gene that acts against P. parasitica or P. palmivora. These findings suggest a novel path to redeploy known R genes against different important plant pathogens.

Item Type: Article
Additional Information: Funding Information: This research was financed by Biotechnology and Biological Sciences Research Council (BBSRC, UK) grants BB/P021646/1, BB/S018832/1, and BB/M017834/1 and the Gatsby Charitable Foundation (Core grant to TSL).
Uncontrolled Keywords: avramr3,phytophthora disease,rxlr-wy effector,rpi-amr3,solanum americanum,potato late blight,molecular biology,plant science ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Science > The Sainsbury Laboratory
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Plant Sciences
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Depositing User: LivePure Connector
Date Deposited: 02 Aug 2022 10:30
Last Modified: 20 Aug 2023 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/87038
DOI: 10.1016/j.molp.2022.07.012


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