Evaluation of chamomile oil and nanoemulgels as a promising treatment option for atopic dermatitis induced in rats

El-Salamouni, Noha S., Ali, Mai M., Abdelhady, Sherien A., Kandil, Lamia S. ORCID: https://orcid.org/0000-0002-5414-5403, Elbatouti, Gihan A. and Farid, Ragwa M. (2020) Evaluation of chamomile oil and nanoemulgels as a promising treatment option for atopic dermatitis induced in rats. Expert Opinion on Drug Delivery, 17 (1). pp. 111-122. ISSN 1744-7593

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Abstract

Background: Atopic dermatitis is a chronic inflammatory skin disease that remarkably affects the quality-of-life of patients. Chamomile oil is used to treat skin inflammations. We evaluated the efficacy of chamomile oil and nanoemulgel formulations as a natural alternative therapeutic option for atopic dermatitis. Research design and methods: Formulations were developed comprising chamomile oil: olive oil (1:1), Tween 20/80 or Gelucire 44/14 as surfactant-cosurfactant mixtures, propylene glycol (10%w/w), water and hydroxypropyl methylcellulose (3%w/w). In-vitro physicochemical characterization, stability testing and in-vivo assessment of inflammatory biomarkers and histopathological examination of skin lesions were conducted in rats induced with atopic dermatitis. Results: Nanoemulgels G1 and X1 which displayed the smallest particle size of 137.5 ± 2.04 and 207.1 ± 5.44 nm, good homogeneity and high zeta-potential values of –26.4 and –32.7 mV were selected as the optimized emulgel. Nanoemulgels were nonirritating of pH value 5.56, readily spreadable, and were physically stable following 10 heating-cooling cycles. Treatment with nanoemulgels showed a two-fold decrease in duration of skin healing and no spongiosis compared to chamomile oil. Levels of biomarkers were reduced after topical application of both nanoemulgels and chamomile oil. Conclusion: Nanoemulgels are a potential cost effective, safe topical carrier system for chamomile in treating atopic dermatitis.

Item Type: Article
Uncontrolled Keywords: atopic dermatitis,chamomile oil,inflammatory biomarkers,nanoemulgel,olive oil,pharmaceutical science ,/dk/atira/pure/subjectarea/asjc/3000/3003
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 21 Jul 2022 11:38
Last Modified: 02 Oct 2022 04:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/86796
DOI: 10.1080/17425247.2020.1699054

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