N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+

Stringer, Tameryn ORCID: https://orcid.org/0000-0002-4439-131X, Melis, Diana R. and Smith, Gregory S. (2019) N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+. Dalton Transactions, 48 (35). pp. 13143-13148. ISSN 1477-9226

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Abstract

Two Rh(III) and Ir(III) half-sandwich quinoline-based complexes were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. These half-sandwich organometallic complexes can also facilitate transfer hydrogenation, by converting β-nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH) in the presence of sodium formate. Co-administration of the iridium(III) complex with sodium formate enhances the antiplasmodial activity in the chloroquine-resistant (K1) strain of Plasmodium falciparum, intimating that metal-mediated transfer hydrogenations can be achieved in malarial parasitic cells.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 19 Jul 2022 13:30
Last Modified: 12 Aug 2022 05:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/86603
DOI: 10.1039/C9DT02030F

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