N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+

Tools

Stringer, Tameryn ORCID: https://orcid.org/0000-0002-4439-131X, Melis, Diana R. and Smith, Gregory S. (2019) N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+. Dalton Transactions, 48 (35). pp. 13143-13148. ISSN 1477-9226

Full text not available from this repository. (Request a copy)

Abstract

Two Rh(III) and Ir(III) half-sandwich quinoline-based complexes were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. These half-sandwich organometallic complexes can also facilitate transfer hydrogenation, by converting β-nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH) in the presence of sodium formate. Co-administration of the iridium(III) complex with sodium formate enhances the antiplasmodial activity in the chloroquine-resistant (K1) strain of Plasmodium falciparum, intimating that metal-mediated transfer hydrogenations can be achieved in malarial parasitic cells.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Chemistry
Related URLs:	https://doi.org/10.1039/C9DT02030F
Depositing User:	LivePure Connector
Date Deposited:	19 Jul 2022 13:30
Last Modified:	24 Oct 2022 16:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/86603
DOI:	10.1039/C9DT02030F

Actions (login required)

View Item