Candidate regions for testicular cancer susceptibility genes

Bishop, D. Timothy and The International Testicular Cancer Linkage Consortium (1998) Candidate regions for testicular cancer susceptibility genes. APMIS, 106 (1-6). pp. 64-72. ISSN 0903-4641

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Although the aetiology of testicular cancer is unknown, a clear familial component has been identified in a number of studies. In an effort to identify susceptibility genes for testicular cancer, the International Testis Cancer Linkage Consortium has been collecting families with multiple cases of testicular cancer. These families have been genotyped for a set of markers across the genome in two separate studies. The family information has also been pooled across the two studies so that the combined evidence can be assessed. While no genomic region gives overwhelming support for a testicular cancer predisposition gene, several regions, notably on chromosomes 3, 5, 12 and 18 show suggestive evidence worthy of further examination. The Consortium is now attempting to identify further families in an attempt to confirm or deny these leads.

Item Type: Article
Uncontrolled Keywords: family studies,linkage,mapping,susceptibility gene,testis cancer,pathology and forensic medicine,immunology and allergy,microbiology (medical),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2734
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 19 Jul 2022 10:30
Last Modified: 03 Nov 2022 16:36
DOI: 10.1111/j.1699-0463.1998.tb01320.x

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