Structural alterations of the rb1 gene in human soft tissue tumours

Stratton, M. R., Williams, S., Fisher, C., Ball, A., Westbury, G., Gusterson, B. A., Fletcher, C. D.M., Knight, J. C., Fung, Y. K., Reeves, B. R. and Cooper, C. S. ORCID: (1989) Structural alterations of the rb1 gene in human soft tissue tumours. British Journal of Cancer, 60 (2). pp. 202-205. ISSN 0007-0920

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Sixty-nine primary soft tissue tumours were examined for alterations of the RB1 gene which has previously been implicated in the genesis of retinoblastoma. In three tumours loss of both alleles of this gene (homozygous deletion) was detected. Two of these, both leiomyosarcomas, contained a chromosomal breakpoint within the RB1 gene, while in the third tumour, a radiation induced sarcoma, complete deletion was observed. Using a probe that detects a polymorphic locus within the RB1 gene we found loss of only one allele (heterozygous deletion) in 33% of soft tissue sarcomas examined, including two leiomyosarcomas, a malignant peripheral nerve sheath tumour, a rhabdomyosarcoma and a chondrosarcoma. When taken together our results suggest that alterations of the RB1 locus may play an important part in the pathogenesis of soft tissue tumours and particularly in leiomyosarcomas which accounted for four of the eight RB1 alterations observed in this study.

Item Type: Article
Uncontrolled Keywords: oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:31
Last Modified: 23 Oct 2022 04:03
DOI: 10.1038/bjc.1989.251

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