Molecular cloning and localization to chromosome 6 of mouse INT1L1 gene

Chan, A. M.L., Hilkens, J., Kroezen, V., Mitchell, P. J., Scambler, P., Wainwright, B. J., Williamson, R. and Cooper, C. S. ORCID: (1989) Molecular cloning and localization to chromosome 6 of mouse INT1L1 gene. Somatic Cell and Molecular Genetics, 15 (6). pp. 555-562. ISSN 0740-7750

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The human INT1L1 gene, which exhibits homology to the protooncogene INT1 is very closely linked to the MET gene and cystic fibrosis locus on human chromosome 7. In the present study we have isolated overlapping genomic clones that correspond to the mouse homolog of the INT1L1 gene and have used the cloned DNA as probes to examine the distribution of the mouse INT1L1 gene within a series of 35 mouse-hamster somatic cell hybrids. These analyses have localized the INT1L1 gene to mouse chromosome 6. In addition, we demonstrate that the mouse INT1L1 and MET genes are coamplified in lines of spontaneously transformed mouse NIH3T3 cells, indicating that these genes may remain closely linked within the mouse genome.

Item Type: Article
Uncontrolled Keywords: genetics,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1311
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:31
Last Modified: 23 Oct 2022 04:03
DOI: 10.1007/BF01534916

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