Primary structure of the met protein tyrosine kinase domain

Chan, A. M.L., King, H. W.S., Tempest, P. R., Deakin, E. A., Cooper, C. S. ORCID: and Brookes, P. (1987) Primary structure of the met protein tyrosine kinase domain. Oncogene, 1 (2). pp. 229-233. ISSN 0950-9232

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The primary structure of the protein tyrosine kinase domain of the human met gene has been determined from cDNA clones prepared from transcripts of the activated human met gene. These analyses reveal that the met kinase domain (located on human chromosome 7) possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. The results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein, which is encoded by human chromosome 1, exhibits homology to laminin B1.

Item Type: Article
Uncontrolled Keywords: molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:31
Last Modified: 23 Oct 2022 04:02

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