Characterization of Human Transforming Genes from Chemically Transformed, Teratocarcinoma, and Pancreatic Carcinoma Cell Lines

Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042, Blair, Donald G., Oskarsson, Marianne K., Tainsky, Michael A., Eader, Lou A. and Vande Woude, George F. (1984) Characterization of Human Transforming Genes from Chemically Transformed, Teratocarcinoma, and Pancreatic Carcinoma Cell Lines. Cancer Research, 44 (1). pp. 1-10. ISSN 0008-5472

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Abstract

Dominant transforming genes that were transferred to mouse N1H3T3 cells by cellular DNAs prepared from a chemically transformed human cell line (MNNG-HOS), a human teratocarcinoma cell line (PA1), and a human pancreatic carcinoma cell line (A1165) were characterized (a) analyzing the repetitive human DNA sequences that were associated with the transforming gene and (b) determining their relationship to the oncogenes of the Harvey (ras”) and Kirsten (rasK) sarcoma viruses and to the human neuroblastoma transforming gene (ras”). The results show that the transforming gene activated in the teratocarcinoma cell line is identical to the neuroblastoma transforming gene and that the transforming gene of the pancreatic carcinoma cell line is a human homologue of rask. In contrast, the transforming gene activated in the chemically transformed human cell line showed no detectable homology to rasK, rasH, and rasN.

Item Type: Article
Uncontrolled Keywords: oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:30
Last Modified: 25 Jul 2022 00:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/86538
DOI:

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