Increased expression and mutation of p53 in choroidal melanoma

Tobal, K., Warren, W., Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042, McCartney, A., Hungerford, J. and Lightman, S. (1992) Increased expression and mutation of p53 in choroidal melanoma. British Journal of Cancer, 66 (5). pp. 900-904. ISSN 0007-0920

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Abstract

Using CM-1 antibody directed against the human p53 protein, high levels of mutant p53 protein expression were found in 12 out of 18 malignant choroidal melanomas. In contrast, we failed to observe elevated p53 expression, indicating the absence of p53 mutation in seven choroidal naevi, a potentially premalignant condition that can progress to form malignant melanoma. For two choroidal melanomas, we demonstrated that high levels of p53 protein were accompanied by exon 7 mutations. The mutations were found at codon 238, TGT→TTT and codon 253, ACC→AGC. These observations suggest that acquisition of abnormalities of the p53 gene may be an important step in the development of malignant melanoma.

Item Type: Article
Additional Information: Funding Information: We would like to thank Dr David Lane for his kind donation of the CM-1 anti-human p53 antibody and the relevant details. We would also like to thank Ms Lisa Sherman for her help with the preparation of this manuscript. This work is supported by Fight for Sight. CSC and WW are supported by the Cancer Research Cam- paign UK.
Uncontrolled Keywords: oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:30
Last Modified: 12 Aug 2022 05:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/86528
DOI: 10.1038/bjc.1992.382

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