The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes

Rocques, Phillppe J., Clark, Jeremy, Ball, Sarah, Crew, Jayne, Gill, Sandra, Christodoulou, Zoe, Borts, Rhona H., Louis, Edward J., Davies, Kay E. and Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042 (1995) The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes. Human Molecular Genetics, 4 (2). pp. 243-249. ISSN 0964-6906

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Abstract

We report that the human gene SB1.8 (DXS423E) encodes a protein of 1233 amino acids that is highly homologous (30% Identity) to the essential yeast protein SMC1 which is required for the segregation of chromosomes at mitosis. Both SB1.8 and SMC1 contain an N-terminal NTP binding site, a central coiled-coil region and a C-terminal helix-loop-helix domain, and have structural features in common with the force generating proteins myosin and kinesin. SB1.8 also exhibits regions of homology and overall structural similarity to the prokaryote (Mycoplasma hyorhinis) protein 115p. Thus SB1.8 and SMC1 are members of a highly conserved and ubiquitous family of proteins that appear to have a fundamental role In cell division. In addition we show that SB1.8 (DXS423E) maps to a cosmid contig that lies centromeric to the OATL2 locus at chromosome Xp11.2.

Item Type: Article
Additional Information: Funding Information: We would like to thank the Cancer Research Campaign and Medical Research Council for supporting this work and Christine Bell for typing the manuscript. PJR was supported by an MRC studentship. RHB and EJL are Wellcome Senior Fellows.
Uncontrolled Keywords: molecular biology,genetics,genetics(clinical) ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:31
Last Modified: 21 Jul 2022 10:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/86512
DOI: 10.1093/hmg/4.2.243

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