Microsatellite instability in human testicular germ cell tumours

Huddart, R. A., Wooster, R., Horwich, A. and Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 (1995) Microsatellite instability in human testicular germ cell tumours. British Journal of Cancer, 72 (3). pp. 642-645. ISSN 0007-0920

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DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.

Item Type: Article
Additional Information: Funding Information: Acknowled We thank Christine Bell for typing this manuscript and Dr M Stratton. Dr P Karran and Professor R Lahue for helpful discussion. This work is funded by grants from the Cancer Research Campaign. RH is supported by a CRC Clinical Research Fellowship.
Uncontrolled Keywords: microsatellite instability,testicular germ cell tumours,oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:31
Last Modified: 23 Oct 2022 04:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/86509
DOI: 10.1038/bjc.1995.387

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