Molecular genetics of soft tissue sarcomas

Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042 and Cornes, Paul (1997) Molecular genetics of soft tissue sarcomas. In: Soft Tissue Sarcomas. Cancer Treatment and Research, 91 . Springer, Boston, MA, pp. 31-50. ISBN 978-1-4613-7805-1

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Abstract

During the past decade considerable progress has been made in elucidating the mechanisms underlying the development of human soft tissue sarcomas. It has been established that certain genetic disorders can predispose to the development of soft tissue sarcomas, and in many cases the individual genes containing the inherited mutation have been cloned and characterized. Cytogenetic studies have identified specific chromosomal translocations in certain types of soft tissue sarcoma, and most of the genes that become altered by these rearrangements have now been isolated. Progress has also been made in identifying genes that control the differentiation of some mesenchymal lineage (e.g., striated muscle). These recent developments are reviewed in this chapter, with particular emphasis being placed on (1) recent advances that have been made in understanding precisely how the genetic alteration found in soft tissue sarcomas may lead to tumor formation and (2) the potential use of genetic markers in tumor diagnosis and prognosis.

Item Type: Book Section
Uncontrolled Keywords: oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:31
Last Modified: 02 Aug 2022 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/86501
DOI: 10.1007/978-1-4615-6121-7_3

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