Fusion of splicing factor genes PSF and NonO (p54(nrb)) to the TFE3 gene in papillary renal cell carcinoma

Clark, Jeremy, Lu, Yong Jie, Sidhar, Sanjiv K., Parker, Chris, Gill, Sandra, Smedley, Damian, Hamoudi, Rifat, Linehan, W. Marston, Shipley, Janet and Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042 (1997) Fusion of splicing factor genes PSF and NonO (p54(nrb)) to the TFE3 gene in papillary renal cell carcinoma. Oncogene, 15 (18). pp. 2233-2239. ISSN 0950-9232

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We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34) observed in papillary renal cell carcinomas results in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix-loop-helix transcription factor gene at Xp11.2. In addition we define an X chromosome inversion inv(X)(p11.2;q12) that results in the fusion of the NonO (p54(nrb)) gene to TFE3. NonO (p54(nrb)), the human homologue of the Drosophila gene NonA(diss) which controls the male courtship song, is closely related to PSF and also believed to be involved in RNA splicing. In each case the rearrangement results in the fusion of almost the entire splicing factor protein to the TFE3 DIVA-binding domain. These observations suggest the possibility of intriguing links between the processes of RNA splicing, DNA transcription and oncogenesis.

Item Type: Article
Additional Information: Funding Information: We thank the Cancer Research Campaign for funding this work and Christine Bell for typing the manuscript.
Uncontrolled Keywords: chromosome translocations,nono (p54(nrb)) splicing factor,psf splicing factor,renal cell carcinoma,tfe3 transcription factor,molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:30
Last Modified: 23 Oct 2022 04:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/86498
DOI: 10.1038/sj.onc.1201394

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