Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

Smedley, Damian, Somers, Gino, Venter, Deon, Chow, Chung Wo, Cooper, Colin ORCID: and Shipley, Janet (1998) Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder. Genes Chromosomes and Cancer, 21 (1). pp. 70-73. ISSN 1045-2257

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Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11- 12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.

Item Type: Article
Uncontrolled Keywords: genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1311
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:30
Last Modified: 23 Oct 2022 04:01
DOI: 10.1002/(SICI)1098-2264(199801)21:1<70::AID-GCC9>3.0.CO;2-5

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