BCL10 is rarely mutated in human prostate carcinoma, small cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

Gill, S., Broni, J., Jefferies, S., Osin, P., Kovacs, G., Maitland, N. J., Eeles, R., Edwards, S. M., Dyer, M. J. S., Willis, T. G. and Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 and the M. P. T. Collaborators, the St George’s Hospital Collaborators (1999) BCL10 is rarely mutated in human prostate carcinoma, small cell lung cancer, head and neck tumours, renal carcinoma and sarcomas. British Journal of Cancer, 80 (10). pp. 1565-1568. ISSN 0007-0920

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We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL 10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to find evidence of somatically acquired mutations of the BCL10 gene suggesting that BCL 10 does not play a major role in the development of these malignancies.

Item Type: Article
Additional Information: Funding Information: We would like to thank the Cancer Research Campaign for funding this work and Christine Bell for typing this manuscript. NJM is supported by Yorkshire Cancer Research. PO is supported by the ‘Breakthrough’ breast cancer charity. MPT Collaborators: S Jefferies1, R Eeles1, J Henk2, M Gore2, P Rhys-Evans2, D Archer2, K Bishop2, E Solomon3, S Hodgson3, M McGurk3, J Hibbert3, M O’Connell3, M Saunders4, M Partridge3, E Chevretton3, F Calman3, K Shotton5, A Brown6, S Whittaker7. 1Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK. 2The Royal Marsden Hospital Trust, Downs Road, Sutton, Surrey SM2 5PT, UK. 3Guys and St Thomas’ and Kings Hospital Trusts, London, UK. 4Mount Vernon Hospital Trust, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK. 5Mid-Kent Oncology Centre, Hermitage Lane, Maidstone, Kent ME16 9QQ, UK. 6Queen Victoria Hospital. 7Royal Surrey County Hospital, Egerton Road, Guildford, Surrey GU2 5XX, UK. St Georges Hospital Collaborators: R Eeles1, R Kirby2, C Corbishley2, W Dunsmuir2. 1See 1 above. 2Urology Unit, St Georges NHS Trust, Blackshaw Road, Tooting, London SW17 0QJ, UK.
Uncontrolled Keywords: bcl 10,head and neck squamous cell cancers,lung cancer,mutation,prostate cancer,renal carcinoma,sarcomas,oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:30
Last Modified: 03 Nov 2022 16:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/86493
DOI: 10.1038/sj.bjc.6690561

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