Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling

Lee, Y. F., John, M., Edwards, S., Clark, J., Flohr, P., Maillard, K., Edema, M., Baker, L., Mangham, D. C., Grimer, R., Wooster, R., Thomas, J. M., Fisher, C., Judson, I. and Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 (2003) Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling. British Journal of Cancer, 88 (4). pp. 510-515. ISSN 0007-0920

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Abstract

In this study, we have used genome-wide expression profiling to categorise synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas (MFHs). Following hierarchical clustering analysis of the expression data, the best match between tumour clusters and conventional diagnosis was observed for synovial sarcomas. Eight of nine synovial sarcomas examined formed a cluster that was characterised by higher expression of a set of 48 genes. In contrast, sarcomas conventionally classified as leiomyosarcomas and MFHs did not match the clusters defined by hierarchical clustering analysis. One major cluster contained a mixture of both leiomyosarcomas and MFHs and was defined by the lower expression of a set of 202 genes. A cluster containing a subgroup of MFHs was also detected. These results may have implications for the classification of soft tissue sarcomas, and are consistent with the view that sarcomas conventionally defined as MFHs do not represent a separate diagnostic category.

Item Type: Article
Additional Information: Funding Information: This work was funded by Cancer Research UK and Alexander Boag Sarcoma Fund. Christine Bell is thanked for her help with typing the manuscript. Dr Ian Giddings and Anne Fletcher are thanked for their expert assistance with IS.
Uncontrolled Keywords: hierarchical clustering,leiomyosarcoma,malignant fibrous histiocytoma,microarray,soft tissue sarcoma,synovial sarcoma,oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 12:30
Last Modified: 16 Aug 2022 13:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/86470
DOI: 10.1038/sj.bjc.6600766

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