Identification of prognostic signatures in breast cancer microarray data using Bayesian techniques

Carrivick, L., Rogers, S., Clark, J., Campbell, C., Girolami, M. and Cooper, C. ORCID: (2005) Identification of prognostic signatures in breast cancer microarray data using Bayesian techniques. Journal of The Royal Society Interface, 3 (8). pp. 367-381. ISSN 1742-5689

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We apply a new Bayesian data analysis technique (latent process decomposition) to four recent microarray datasets for breast cancer. Compared to hierarchical cluster analysis, for example, this technique has advantages such as objective assessment of the optimal number of sample or gene clusters in the data, penalization of overcomplex models fitting to noise in the data and a common latent space of explanatory variables for samples and genes. Our analysis provides a clearer insight into these datasets, enabling assignment of patients to one of four principal processes, each with a distinct clinical outcome. One process is indolent and associated with under-expression across a number of genes associated with tumour growth. One process is associated with over expression of GRB7 and ERBB2. The most aggressive process is associated with abnormal expression of transcription factor genes, including members of the FOX family of transcription factor genes.

Item Type: Article
Uncontrolled Keywords: breast cancer,cluster analysis,microarray data,biotechnology,biophysics,bioengineering,biomaterials,biochemistry,biomedical engineering,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 12:30
Last Modified: 23 Oct 2022 04:00
DOI: 10.1098/rsif.2005.0093

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