Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer

Attard, G., Clark, J., Ambroisine, L., Mills, I. G., Fisher, G., Flohr, P., Reid, A., Edwards, S., Kovacs, G., Berney, D., Foster, C., Massie, C. E., Fletcher, A., De Bono, J. S., Scardino, P., Cuzick, J. and Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 (2008) Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer. British Journal of Cancer, 99 (2). pp. 314-320. ISSN 0007-0920

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A fluorescence in situ hybridisation (FISH) assay has been used to screen for ETV1 gene rearrangements in a cohort of 429 prostate cancers from patients who had been diagnosed by trans-urethral resection of the prostate. The presence of ETV1 gene alterations (found in 23 cases, 5.4%) was correlated with higher Gleason Score (P=0.001), PSA level at diagnosis (P=<0.0001) and clinical stage (P=0.017) but was not linked to poorer survival. We found that the six previously characterised translocation partners of ETV1 only accounted for 34% of ETV1 re-arrangements (eight out of 23) in this series, with fusion to the androgen-repressed gene C15orf21 representing the commonest event (four out of 23). In 5′-RACE experiments on RNA extracted from formalin-fixed tissue we identified the androgen-upregulated gene ACSL3 as a new 5′-translocation partner of ETV1. These studies report a novel fusion partner for ETV1 and highlight the considerable heterogeneity of ETV1 gene rearrangements in human prostate cancer.

Item Type: Article
Additional Information: Funding Information: This work was funded by Cancer Research UK, the National Cancer Research Institute, National Institutes of Health (SPORE) the Grand Charity of Freemasons, The Rosetrees Trust, The Orchid Appeal and the Koch Foundation. Funding bodies had no involvement in the design and conduct of the study, or in collection management, analysis and interpretation of the data, or in preparation, review or approval of the paper. We thank Christine Bell for help with typing the paper.
Uncontrolled Keywords: acsl3,acsl3:etv1 fusion,etv1,prostate cancer,oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 12:30
Last Modified: 23 Oct 2022 04:00
URI: https://ueaeprints.uea.ac.uk/id/eprint/86461
DOI: 10.1038/sj.bjc.6604472

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