Hormone-sensitive prostate cancer:A case of ETS gene fusion heterogeneity

Attard, G., Jameson, C., Moreira, J., Flohr, P., Parker, C., Dearnaley, D., Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 and De Bono, J. S. (2008) Hormone-sensitive prostate cancer:A case of ETS gene fusion heterogeneity. Journal of Clinical Pathology, 62 (4). pp. 373-376. ISSN 0021-9746

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Fusion of the hormone-regulated gene TMPRSS2 with ERG occurs in 50-70% of prostate cancers; fusions of ETV1 with one of several partners occur in approximately 10% of prostate cancers. These two translocations are mutually exclusive. The presence of subclasses of these chromosomal rearrangements may indicate worse prognosis, with the subclass 2+Edel, which has duplication of TMPRSS2:ERG fusion sequences, indicating particularly poor survival. However as this case shows, significant heterogeneity can exist with ERG and ETV7 rearrangements occurring in both prostate intra-epithelial neoplasia and cancer in the same prostatectomy specimen and with adjacent cancer areas containing a single copy, duplication and even triplication of the rearranged locus. As the majority of ETS gene fusions are hormone regulated, they could explain the pathogenesis underlying exquisitely hormone-sensitive prostate cancer. This is exemplified by the case presented here of a patient diagnosed in 1991 who remains asymptomatic and chemotherapy-naive after having long-lasting tumour responses to multiple lines of systemic hormonal treatments.

Item Type: Article
Uncontrolled Keywords: pathology and forensic medicine,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2734
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 12:30
Last Modified: 23 Oct 2022 04:00
URI: https://ueaeprints.uea.ac.uk/id/eprint/86458
DOI: 10.1136/jcp.2008.061515

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