The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer

Shan, L., Ambroisine, L., Clark, J., Yáñez-Muñoz, R. J., Fisher, G., Kudahetti, S. C., Yang, J., Kia, S., Mao, X., Fletcher, A., Flohr, P., Edwards, S., Attard, G., De-Bono, J., Young, B. D., Foster, C. S., Reuter, V., Moller, H., Oliver, T. D., Berney, D. M., Scardino, P., Cuzick, J., Cooper, C. S. ORCID: and Lu, Y. J. (2010) The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer. Prostate Cancer and Prostatic Diseases, 13 (2). pp. 117-125. ISSN 1365-7852

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Our previous work identified a chromosomal translocation t(4;6) in prostate cancer cell lines and primary tumors. Using probes located on 4q22 and 6q15, the breakpoints identified in LNCaP cells, we performed fluorescence in situ hybridization analysis to detect this translocation in a large series of clinical localized prostate cancer samples treated conservatively. We found that t(4;6)(q22;q15) occurred in 78 of 667 cases (11.7%). The t(4;6)(q22;q15) was not independently associated with patient outcome. However, it occurs more frequently in high clinical T stage, high tumor volume specimens and in those with high baseline PSA (P=0.001, 0.001 and 0.01, respectively). The t(4;6)(q22;q15) occurred more frequently in samples with two or more TMPRSS2:ERG fusion genes caused by internal deletion than in samples without these genomic alterations, but this correlation is not statistically significant (P=0.0628). The potential role of this translocation in the development of human prostate cancer is discussed.

Item Type: Article
Additional Information: Funding Information: We thank Olabisi Onilude, Yongwei Yu and Andrew Clear for technical assistance. This work was funded by Orchid Cancer Appeal, Cancer Research UK, Prostate Research Campaign UK, the NCRI Prostate Cancer Collaborative, The Prostate Cancer Charity, The Rosetree Trust and the Grand Charity of Freemasons.
Uncontrolled Keywords: chromosome translocation,genomic instability,prognosis,oncology,urology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 12:30
Last Modified: 23 Oct 2022 03:59
DOI: 10.1038/pcan.2010.2

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