High-density tissue microarrays from prostate needle biopsies

McCarthy, F., Dennis, N., Flohr, P., Jhavar, S., Parker, C. and Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 (2010) High-density tissue microarrays from prostate needle biopsies. Journal of Clinical Pathology, 64 (1). pp. 88-90. ISSN 0021-9746

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Abstract

* Background: Formalin-fixed prostate biopsies are frequently the only tissue collected at the time of prostate cancer diagnosis. There is therefore a requirement for techniques that allow the use of these prostate biopsy specimens in a high-throughput analysis of immunohistochemical and fluorescence-in-situ- hybridisation-detected biomarkers. * Methods: The authors have previously described methods that allow tissue microarray (TMA) construction from prostate biopsies. Here, we describe significant technical innovations that provide an easier and more robust system of biopsy-TMA construction. * Results and discussion: The TMAs produced are of a high density (up to 104 cores each, 8X13) and allow a multiplex analysis of biomarkers in the context of clinical trials.

Item Type: Article
Uncontrolled Keywords: pathology and forensic medicine,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2734
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 12:30
Last Modified: 12 Aug 2022 05:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/86454
DOI: 10.1136/jcp.2010.082339

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