Proliferating bipotential glial progenitor cells in adult rat optic nerve

Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 and Raff, Martin C. (1986) Proliferating bipotential glial progenitor cells in adult rat optic nerve. Nature, 319 (6053). pp. 499-502. ISSN 0028-0836

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Abstract

We have shown previously that the rat optic nerve contains three types of macroglial cells - Oligodendrocytes and two types of astrocytes - Which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16)1, while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7-10 (P7-10), respectively 2. Here we report that proliferating bipotential oligoden-drocyte- type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.

Item Type: Article
Uncontrolled Keywords: general ,/dk/atira/pure/subjectarea/asjc/1000
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 17:30
Last Modified: 17 Jul 2022 00:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/86407
DOI: 10.1038/319499a0

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