A developmental analysis of oligodendroglial integrins in primary cells:Changes in αv-associated β subunits during differentiation

Milner, R. and Ffrench-Constant, C. ORCID: https://orcid.org/0000-0002-5621-3377 (1994) A developmental analysis of oligodendroglial integrins in primary cells:Changes in αv-associated β subunits during differentiation. Development, 120 (12). pp. 3497-3506. ISSN 0950-1991

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Abstract

We have examined the expression of integrins on primary oligodendroglial cells during the differentiation of the proliferative oligodendrocyte precursor (O-2A progenitor) cell to the postmitotic oligodendrocyte. Cells of the oligodendrocyte lineage expressed a limited repertoire of integrins: α6β1 and αv integrins including αvβ1, αvβ3 and αvβ5, as well as a potentially novel integrin αvβ80kDa. Integrin expression was developmentally regulated; during differentiation αvβ1 was reduced and αvβ5 upregulated. These results suggest that laminin and vitronectin are important extracellular matrix ligands for oligodendrocytes, and provide a rational explanation for previous observations that RGD peptides inhibit the expression of myelin-specific genes. They also suggest a simple model by which switching of integrin β subunits might regulate differentiation. As chimeric β1 integrins with a β5 cytoplasmic domain support proliferation less well than normal β1 integrins the switch from αvβ1 to αvβ5 might play a key instructive role in the cessation of proliferation and subsequent differentiation.

Item Type: Article
Uncontrolled Keywords: α6β1,αvβ1,αvβ5,differentiation,integrin,o-2a progenitor cell,oligodendrocyte,oligodendrocyte precursor,proliferation,molecular biology,developmental biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 17:30
Last Modified: 12 Aug 2022 05:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/86394
DOI:

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