Embryonic fibronectins are up‐regulated following peripheral nerve injury in rats

Mathews, Greta A. and Ffrench‐Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (1995) Embryonic fibronectins are up‐regulated following peripheral nerve injury in rats. Journal of Neurobiology, 26 (2). pp. 171-188. ISSN 0022-3034

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Fibronectin mRNAs that include the alternatively spliced exons EIIIA, EIIIB, and V are prevalent during embryogenesis, and EIIIA and EIIIB reappear during wound healing. Using ribonuclease protection analyses, we found an up‐regulation of V120 (containing the α4β1 integrin binding site), as well as EIIIA, and EIIIB in fibronectin mRNAs in the crush‐injured adult rat sciatic nerve. In situ hybridization using splice variant‐specific probes revealed that cells within endoneurial tubes of the injured nerve synthesize these embryonic forms of fibronectin. Our results suggest that embryonic fibronectins synthesized within the nerve contribute to the permissiveness of the peripheral nervous system to axon regrowth and a mechanism by which alternative splicing of the V region in fibronectin mRNA could enhance nervous system regeneration.

Item Type: Article
Uncontrolled Keywords: alternative splicing,axon regeneration,fibronectin,rnase protection analysis,neuroscience(all),cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 17:30
Last Modified: 23 Oct 2022 03:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/86390
DOI: 10.1002/neu.480260203

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