Inhibition of oligodendrocyte precursor motility by oligodendrocyte processes:Implications for transplantation-based approaches to multiple sclerosis

Jefferson, Samantha, Jacques, Thomas, Kiernan, B. W., Scott-Drew, Suzanna, Milner, Richard and Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (1997) Inhibition of oligodendrocyte precursor motility by oligodendrocyte processes:Implications for transplantation-based approaches to multiple sclerosis. Multiple Sclerosis, 3 (2). pp. 162-167. ISSN 1352-4585

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Abstract

Transplantation of oligodendrocyte precursor cells represents a promising approach to the treatment of the chronic demyelinated lesions of multiple sclerosis. In view of the multi-focal nature of the disease it will be necessary for the transplanted oligodendrocyte precursor cells to migrate through normal white matter between lesions. Work in other systems has shown that differentiated oligodendrocytes within white matter express molecules inhibitory for axon outgrowth. In light of this we have examined the effect of oligodendrocytes on the migration of oligodendrocyte precursors in vitro using time lapse video microscopy. We find that oligodendrocytes induce collapse and loss of motility in oligodendrocyte precursor processes, with this effect being lost as oligodendrocytes undergo programmed cell death. We conclude that the inhibitory factors present on differentiated oligodendrocytes may prevent effective migration between lesion in vivo, and that strategies to overcome this inhibition may be required for successful repair.

Item Type: Article
Uncontrolled Keywords: apotosis,collapse,collapsin,growth cone,o-2a progenitor,semaphorin,neurology,clinical neurology ,/dk/atira/pure/subjectarea/asjc/2800/2808
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 16:30
Last Modified: 13 Aug 2022 02:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/86381
DOI: 10.1177/135245859700300220

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